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It is plastic or aluminium. Chemical compounds, like PVC and its blends with another substances are used. They can be quickly formed with the help of special machines under high temperature conditions. After the wanted shape of the blister is ready, the tablets are put inside it. Then, they are closed by the lid. It is usually fabricated from aluminium or polymer foil. During tablet packaging process, a lot of factors must be taken into account. The substrate material which is used must not react with the drug.
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It has to be tough enough to protect the tablets from cracking. At the same time the final packaging must be user-friendly. Elderly patients must be able to unpack it without any trouble, but not the kids. It is quite difficult to design this sort of blister.